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Article

AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery

16 Nov 2020

Abstract excerpt

Adeno-associated virus (AAV) is one of the most commonly used vectors for gene therapy, and the applications for AAV-delivered therapies are numerous. However, the current state of technology is limited by the low efficiency with which most AAV vectors transduce skeletal muscle tissue. We demonstrate that vector efficiency can be enhanced by modifying the AAV capsid with a peptide that binds a receptor highly...

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PMID: 33313337
DOI: 10.1016/j.omtm.2020.11.004

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