Article

Using a barcoded AAV capsid library to select for novel clinically relevant gene therapy vectors

2019-06-27

Abstract excerpt

<h4>ABSTRACT:</h4> While gene transfer using recombinant adeno-associated viral (rAAV) vectors have shown success in some clinical trials, there remain many tissues that are not well transduced. Because of the recent success in reprogramming islet derived cells into functional β-cells in animal models, we constructed two highly complex barcoded replication competent capsid shuffled libraries and selected for high...

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Literature Corpus work: 11b6bb30-bd3e-51f4-8f25-275f9f953beb
DOI: 10.1101/683672

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