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Article

DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147).

Journal of the National Cancer Institute - 1 Dec 2014

Lee Adam M, Shi Qian, Pavey Emily, Alberts Steven R, Sargent Daniel J, Sinicrope Frank A, Berenberg Jeffrey L, Goldberg Richard M, Diasio Robert B

Abstract excerpt

BACKGROUND: Previous studies have suggested the potential importance of three DPYD variants (DPYD*2A, D949V, and I560S) with increased 5-FU toxicity. Their individual associations, however, in 5-FU-based combination therapies, remain controversial and require further systematic study in a large patient population receiving comparable treatment regimens with uniform clinical data. METHODS: We genotyped 2886 stage...

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Identifiers

PMID: 25381393
DOI: 10.1093/jnci/dju298
PMCID: PMC4271081

Genes

DPYD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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