Article
Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance).
Pharmacogenetics and genomics - 1 Mar 2016
Lee Adam M, Shi Qian, Alberts Steven R, Sargent Daniel J, Sinicrope Frank A, Berenberg Jeffrey L, Grothey Axel, Polite Blase, Chan Emily, Gill Sharlene, Kahlenberg Morton S, Nair Suresh G, Shields Anthony F, Goldberg Richard M, Diasio Robert B
Abstract excerpt
Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, in extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account for only a small proportion of toxic cases. In the current study, we assessed DPYD variants suggested to correlate with 5-FU toxicity, a deep intronic...
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