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Article

Crystal structure of the nonerythroid alpha-spectrin tetramerization site reveals differences between erythroid and nonerythroid spectrin tetramer formation.

The Journal of biological chemistry - 7 May 2010

Mehboob Shahila, Song Yuanli, Witek Marta, Long Fei, Santarsiero Bernard D, Johnson Michael E, Fung Leslie W-M

Abstract excerpt

We have solved the crystal structure of a segment of nonerythroid alpha-spectrin (alphaII) consisting of the first 147 residues to a resolution of 2.3 A. We find that the structure of this segment is generally similar to a corresponding segment from erythroid alpha-spectrin (alphaI) but exhibits unique differences with functional significance. Specific features include the following: (i) an irregular and frayed...

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Identifiers

PMID: 20228407
DOI: 10.1074/jbc.M109.080028
PMCID: PMC2863205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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