Article
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation.
Drug design, development and therapy - 1 Jan 2015
Liu Jinghua, Li Jianbo, Fu Weiwei, Tang Jiacheng, Feng Xu, Chen Jiang, Liang Yuelong, Jin Ren'an, Xie Anyong, Cai Xiujun
Abstract excerpt
Liver cirrhosis is a chronic liver disease caused by chronic liver injury, which activates hepatic stellate cells (HSCs) and the secretion of extracellular matrix (ECM). Cirrhosis accounts for an extensive level of morbidity and mortality worldwide, largely due to lack of effective treatment options. In this study, we have constructed a fusion protein containing matrix metal-loproteinase 8 (MMP-8) and the human...
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