Article
CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer.
Neoplasia (New York, N.Y.) - 1 Oct 2014
Lu Hai, Yan Carol, Quan Xin Xin, Yang Xinping, Zhang Jialing, Bian Yansong, Chen Zhong, Van Waes Carter
Abstract excerpt
Cancer stem cells (CSC) and genes have been linked to cancer development and therapeutic resistance, but the signaling mechanisms regulating CSC genes and phenotype are incompletely understood. CK2 has emerged as a key signal serine/threonine kinase that modulates diverse signal cascades regulating cell fate and growth. We previously showed that CK2 is often aberrantly expressed and activated in head and neck...
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