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Article

STAT3 blockade enhances the efficacy of conventional chemotherapeutic agents by eradicating head neck stemloid cancer cell.

Oncotarget - 8 Dec 2015

Bu Lin-Lin, Zhao Zhi-Li, Liu Jian-Feng, Ma Si-Rui, Huang Cong-Fa, Liu Bing, Zhang Wen-Feng, Sun Zhi-Jun

Abstract excerpt

Signaling transducer and activator 3 (STAT3) and cancer stem cells (CSCs) have garnered huge attention as a therapeutic focus, based on evidence that they may represent an etiologic root of tumor initiation and radio-chemoresistance. Here, we investigated the high phosphorylation status of STAT3 (p-STAT3) and its correlation with self-renewal markers in head neck squamous cell carcinoma (HNSCC). Over-expression...

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Source

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Identifiers

PMID: 26556875
DOI: 10.18632/oncotarget.5986
PMCID: PMC4747200

Genes

STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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