Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation.

Oncotarget - 6 Sept 2016

Shen Yao-An, Wang Chia-Yu, Chuang Hui-Yen, Hwang John Jeng-Jong, Chi Wei-Hsin, Shu Chih-Hung, Ho Ching-Yin, Li Wing-Yin, Chen Yann-Jang

Abstract excerpt

Cell surface proteins such as CD44 and CD24 are used to distinguish cancer stem cells (CSCs) from the bulk-tumor population. However, the molecular functionalities of CD24 and CD44, and how these two molecules coordinate in CSCs remain poorly understood. We found that nasopharyngeal carcinoma (NPC) cells with high expression of CD44 and CD24 proteins presented with pronounced CSC properties. Accordingly, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD24 Antigen
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

Share to Hyaluronan Receptors

Share to Mice, Inbred NOD

Share to Nasopharyngeal Carcinoma

Share to Nasopharyngeal Neoplasms

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 27521216
DOI: 10.18632/oncotarget.11113
PMCID: PMC5295435

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation.PMID 27521216Read ↗

Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal CarcinomaSemantic proximity Read ↗

Embryonic Stem Cells Markers SOX2, OCT4 and Nanog Expression and Their Correlations with Epithelial-Mesenchymal Transition in Nasopharyngeal CarcinomaSemantic proximity Read ↗

CD44(high)CD24(low) molecular signature determines the Cancer Stem Cell and EMT phenotype in Oral Squamous Cell Carcinoma.Semantic proximity Read ↗

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.Semantic proximity Read ↗

New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulationSemantic proximity Read ↗

Identification and characterization of CD133+CD44+ cancer stem cells from human laryngeal squamous cell carcinoma cell linesSemantic proximity Read ↗

Epstein-Barr Virus Latent Membrane Protein 1 Induces Cancer Stem/Progenitor-Like Cells in Nasopharyngeal Epithelial Cell LinesSemantic proximity Read ↗

Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signalingSemantic proximity Read ↗

Identification of Cancer Stem-like CD44+ Cells in Human Nasopharyngeal Carcinoma Cell LineSemantic proximity Read ↗

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic TargetSemantic proximity Read ↗

Cancer stem-like cells enriched with CD29 and CD44 markers exhibit molecular characteristics with epithelial-mesenchymal transition in squamous cell carcinoma.Semantic proximity Read ↗

Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.