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Article

NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos.

Disease models & mechanisms - 1 Mar 2013

Mercier Sandra, David Véronique, Ratié Leslie, Gicquel Isabelle, Odent Sylvie, Dupé Valérie

Abstract excerpt

Holoprosencephaly (HPE) is a common congenital defect that results from failed or incomplete forebrain cleavage. HPE is characterized by a wide clinical spectrum, with inter- and intrafamilial variability. This heterogeneity is not well understood and it has been suggested that HPE involves a combination of multiple gene mutations. In this model, several mutated alleles or modifying factors are presumed to act in...

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Identifiers

PMID: 23264560
DOI: 10.1242/dmm.010132
PMCID: PMC3597036

Genes

NODAL
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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