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Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

28 Mar 2011

Abstract excerpt

Multidrug resistance caused by the overexpression of ABC drug transporters is a major obstacle in clinical cancer chemotherapy. For several years, it appeared that direct inhibition of ABC transporters would be the cheapest and most efficient way to combat this problem. Unfortunately, progress in finding a potent, selective inhibitor to modulate ABC transporters and restore drug sensitivity in multidrug-resistant...

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PMID: 21118092
DOI: 10.2174/138920111795163887

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