Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer

1 Jan 2014

Abstract excerpt

Little is known about the possible oncogenic roles of genes encoding for the phosphatidylinositol 4-kinases, a family of enzymes that regulate an early step in phosphoinositide signalling. To address this issue, the mutational status of all four human phosphatidylinositol 4-kinases genes was analyzed across 852 breast cancer samples using the COSMIC data resource. Point mutations in the phosphatidylinositol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Genomics and Rare Diseases
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25368680
DOI: 10.7150/jca.9794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast CancerPMID 25368680Read ↗

PI-PLCβ1 gene copy number alterations in breast cancer.Semantic proximity Read ↗

Elevated PI3K signaling drives multiple Breast Cancer subtypesSemantic proximity Read ↗

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality.Semantic proximity Read ↗

PI3K mutations in breast cancer: prognostic and therapeutic implicationsSemantic proximity Read ↗

The PIK3CA gene is mutated with high frequency in human breast cancersSemantic proximity Read ↗

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.Semantic proximity Read ↗

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cellsSemantic proximity Read ↗

Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancerSemantic proximity Read ↗

Targetable Alterations in Invasive Pleomorphic Lobular Carcinoma of the BreastSemantic proximity Read ↗

Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma MultiformeSemantic proximity Read ↗

Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness.Semantic proximity Read ↗

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.