Article
B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.
The Journal of experimental medicine - 16 Jan 2009
Cariappa Annaiah, Takematsu Hiromu, Liu Haoyuan, Diaz Sandra, Haider Khaleda, Boboila Cristian, Kalloo Geetika, Connole Michelle, Shi Hai Ning, Varki Nissi, Varki Ajit, Pillai Shiv
Abstract excerpt
We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of alpha2-6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and...
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