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HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells.

AIDS (London, England) - 20 Feb 2010

Prendergast Andrew, Prado Julia G, Kang Yu-Hoi, Chen Fabian, Riddell Lynn A, Luzzi Graz, Goulder Philip, Klenerman Paul

Abstract excerpt

OBJECTIVE: CD4 T-cell depletion is central to HIV pathogenesis. However, the relative impact of HIV on Th17 and regulatory T cell (Treg) subsets remains unclear. CD161 CD4 cells are a recently identified, gut-homing Th17 precursor population. The balance between pro-inflammatory Th17 and immunoregulatory Tregs may be critical in HIV pathogenesis. This study addressed changes in CD161, Th17 and Treg subsets during...

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PMID: 20071976
DOI: 10.1097/QAD.0b013e3283344895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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