Article
Baseline levels of soluble CD14 and CD16+56- natural killer cells are negatively associated with response to interferon/ribavirin therapy during HCV-HIV-1 coinfection.
The Journal of infectious diseases - 15 Sept 2012
Anthony Donald D, Conry Sara J, Medvik Kathy, Sandhya Rani M R, Falck-Ytter Yngve, Blanton Ronald E, Lederman Michael M, Rodriguez Benigno, Landay Alan L, Sandberg Johan K
Abstract excerpt
Disease progression of human immunodeficiency virus type 1 (HIV-1) is associated with immune activation. Activation indices are higher during coinfection of hepatitis C virus (HCV) and HIV. The effect of immune activation on interferon α (IFN-α) therapy response is unknown. We evaluated soluble CD14 (sCD14) and natural killer (NK)-cell subsets at baseline, and during pegIFN-α2a/ribavirin therapy in HCV-HIV...
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