Article
IL-10 induces activated phenotypes of monocytes observed in virally-suppressed HIV-1-infected individuals.
Biochemical and biophysical research communications - 15 Oct 2024
Takahashi Naofumi, Eltalkhawy Youssef M, Nasu Kanako, Abdelnaser Randa A, Monde Kazuaki, Habash Sara A, Nasser Hesham, Hiyoshi Masateru, Ishimoto Takatsugu, Suzu Shinya
Abstract excerpt
Despite viral suppression by effective combined antiretroviral therapy, HIV-1-infected individuals have an increased risk of non-AIDS-related overall morbidity, which is due to the persistent chronic inflammation exemplified by the activation of monocytes, such as increased CD16high subset, and elevated plasma level of soluble CD163 (sCD163) and soluble CD14 (sCD14). Here, we show that IL-10, which has been...
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