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Article

Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability.

PloS one - 1 Jan 2014

Deepthi Angeline, Liew Chong Wai, Liang Zhao-Xun, Swaminathan Kunchithapadam, Lescar Julien

Abstract excerpt

Large-scale production of bis-3'-5'-cyclic-di-GMP (c-di-GMP) would facilitate biological studies of numerous bacterial signaling pathways and phenotypes controlled by this second messenger molecule, such as virulence and biofilm formation. C-di-GMP constitutes also a potentially interesting molecule as a vaccine adjuvant. Even though chemical synthesis of c-di-GMP can be done, the yields are incompatible with...

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Identifiers

PMID: 25360685
DOI: 10.1371/journal.pone.0110912
PMCID: PMC4215984

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Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability.PMID 25360685Read ↗

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