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Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice.

Blood - 18 Dec 2014

Kübler Ayline, Woiterski Jeanette, Witte Kai-Erik, Bühring Hans-Jörg, Hartwig Udo F, Ebinger Martin, Oevermann Lena, Mezger Markus, Herr Wolfgang, Lang Peter, Handgretinger Rupert, Münz Christian, André Maya C

Abstract excerpt

Therapeutic natural killer (NK)-cell-mediated alloreactivity toward acute myeloid leukemia has largely been attributed to mismatches between killer immunoglobulin-like receptors (KIRs) on NK cells and their ligands, HLA class I molecules, on target cells. While adult acute B-cell precursor leukemia (BCP-ALL) appears to be resistant to NK-cell-mediated lysis, recent data indicate that pediatric BCP-ALL might yet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Killer Cells, Natural

Share to Mice, Inbred NOD

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, KIR

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Source

Identifiers

PMID: 25359989
DOI: 10.1182/blood-2014-05-572743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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