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Article

Fast and accurate site frequency spectrum estimation from low coverage sequence data.

Bioinformatics (Oxford, England) - 1 Mar 2015

Han Eunjung, Sinsheimer Janet S, Novembre John

Abstract excerpt

MOTIVATION: The distribution of allele frequencies across polymorphic sites, also known as the site frequency spectrum (SFS), is of primary interest in population genetics. It is a complete summary of sequence variation at unlinked sites and more generally, its shape reflects underlying population genetic processes. One practical challenge is that inferring the SFS from low coverage sequencing data in a...

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Identifiers

PMID: 25359894
DOI: 10.1093/bioinformatics/btu725
PMCID: PMC4341071

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Source receipt: pubmed, retrieved 7 Sept 2026.

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