Article
Population genomics based on low coverage sequencing: how low should we go?
Molecular ecology - 1 Jun 2013
Alex Buerkle C, Gompert Zachariah
Abstract excerpt
Research in molecular ecology is now often based on large numbers of DNA sequence reads. Given a time and financial budget for DNA sequencing, the question arises as to how to allocate the finite number of sequence reads among three dimensions: (i) sequencing individual nucleotide positions repeatedly and achieving high confidence in the true genotype of individuals, (ii) sampling larger numbers of individuals...
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