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Article

Estimation of site frequency spectra from low-coverage sequencing data using stochastic EM reduces overfitting, runtime, and memory usage.

Genetics - 30 Nov 2022

Rasmussen Malthe Sebro, Garcia-Erill Genís, Korneliussen Thorfinn Sand, Wiuf Carsten, Albrechtsen Anders

Abstract excerpt

The site frequency spectrum is an important summary statistic in population genetics used for inference on demographic history and selection. However, estimation of the site frequency spectrum from called genotypes introduces bias when working with low-coverage sequencing data. Methods exist for addressing this issue but sometimes suffer from 2 problems. First, they can have very high computational demands, to...

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PMID: 36173322
DOI: 10.1093/genetics/iyac148
PMCID: PMC9713400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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