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Article

CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions.

American journal of physiology. Cell physiology - 1 Jan 2015

Shirure Venktesh S, Liu Tiantian, Delgadillo Luis F, Cuckler Chaz M, Tees David F J, Benencia Fabian, Goetz Douglas J, Burdick Monica M

Abstract excerpt

Adhesion of circulating tumor cells to vascular endothelium is mediated by specialized molecules that are functional under shear forces exerted by hematogenous flow. Endothelial E-selectin binding to glycoforms of CD44 mediates shear-resistant cell adhesion in numerous physiological and pathological conditions. However, this pathway is poorly understood in breast cancer and is the focus of the present...

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Identifiers

PMID: 25339657
DOI: 10.1152/ajpcell.00094.2014
PMCID: PMC4281670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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