Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human breast progenitor cell numbers are regulated by WNT and TBX3.

PloS one - 1 Jan 2014

Arendt Lisa M, St Laurent Jessica, Wronski Ania, Caballero Silvia, Lyle Stephen R, Naber Stephen P, Kuperwasser Charlotte

Abstract excerpt

BACKGROUND: Although human breast development is mediated by hormonal and non-hormonal means, the mechanisms that regulate breast progenitor cell activity remain to be clarified. This limited understanding of breast progenitor cells has been due in part to the lack of appropriate model systems to detect and characterize their properties. METHODS: To examine the effects of WNT signaling and TBX3 expression on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Estrogens
Share to Lentivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-6

Share to Mice, Inbred NOD

Share to Primary Cell Culture

Share to Progesterone

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25350852
DOI: 10.1371/journal.pone.0111442
PMCID: PMC4211891

Genes

TBX3
WNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human breast progenitor cell numbers are regulated by WNT and TBX3.PMID 25350852Read ↗

Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epitheliumSemantic proximity Read ↗

Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Semantic proximity Read ↗

Mammary stem cells and progenitors: targeting the roots of breast cancer for preventionSemantic proximity Read ↗

The mammary cellular hierarchy and breast cancerSemantic proximity Read ↗

Epithelial progenitors in the normal human mammary gland.Semantic proximity Read ↗

Differential Expression of Wnt Signaling Molecules Between Pre- and Postmenopausal Endometrial Epithelial Cells Suggests a Population of Putative Epithelial Stem/Progenitor Cells Reside in the Basalis LayerSemantic proximity Read ↗

Rare somatic cells from human breast tissue exhibit extensive lineage plasticitySemantic proximity Read ↗

CCAAT/Enhancer Binding Protein Beta Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary GlandSemantic proximity Read ↗

Luminal progenitors restrict their lineage potential during mammary gland development.Semantic proximity Read ↗

Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast.Semantic proximity Read ↗

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiationSemantic proximity Read ↗

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.