Article
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia.
The pharmacogenomics journal - 1 Jun 2015
den Hoed M A H, Lopez-Lopez E, te Winkel M L, Tissing W, de Rooij J D E, Gutierrez-Camino A, Garcia-Orad A, den Boer E, Pieters R, Pluijm S M F, de Jonge R, van den Heuvel-Eibrink M M
Abstract excerpt
Methotrexate (MTX) is an effective and toxic chemotherapeutic drug in the treatment of pediatric acute lymphoblastic leukemia(ALL). In this prospective study, we aimed to identify metabolic and genetic determinants of MTX toxicity. One hundred and thirty-four Dutch pediatric ALL patients were treated with four high infusions MTX (HD-MTX: 5 g m(-2)) every other week according to the DCOG-ALL-10 protocol. Mucositis...
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