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Article

Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

9 Jul 2018

Abstract excerpt

BACKGROUND: Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methylation. We hypothesize that MTX inhibits DNA methylation, which results into adverse effects. We studied DNA...

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PMID: 29985926
DOI: 10.1371/journal.pone.0199574

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