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Article

Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608.

Nature immunology - 1 Dec 2006

Zhang Feng, Thomas Lance R, Oltz Eugene M, Aune Thomas M

Abstract excerpt

The products of recombination-activating gene 1 (Rag1) and Rag2 are required for T cell receptor gene assembly and thymocyte maturation, yet their transcriptional control mechanisms remain unclear. A congenic strain (called 'ZORI' here) with defects in Rag1 and Rag2 expression, thymocyte maturation and peripheral T cell homeostasis has been developed. Here, we mapped the mutation in this strain to a chromosome 18...

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Identifiers

PMID: 17057722
DOI: 10.1038/ni1397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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