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Article

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

PloS one - 1 Jan 2014

Karp Natasha A, Speak Anneliese O, White Jacqueline K, Adams David J, Hrabé de Angelis Martin, Hérault Yann, Mott Richard F

Abstract excerpt

A significant challenge facing high-throughput phenotyping of in-vivo knockout mice is ensuring phenotype calls are robust and reliable. Central to this problem is selecting an appropriate statistical analysis that models both the experimental design (the workflow and the way control mice are selected for comparison with knockout animals) and the sources of variation. Recently we proposed a mixed model suitable...

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Identifiers

PMID: 25343444
DOI: 10.1371/journal.pone.0111239
PMCID: PMC4208881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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