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Article

Multivariate phenotype analysis enables genome-wide inference of mammalian gene function.

PLoS biology - 1 Aug 2022

Nicholson George, Morgan Hugh, Ganjgahi Habib, Brown Steve D M, Mallon Ann-Marie, Holmes Chris

Abstract excerpt

The function of the majority of genes in the human and mouse genomes is unknown. Investigating and illuminating this dark genome is a major challenge for the biomedical sciences. The International Mouse Phenotyping Consortium (IMPC) is addressing this through the generation and broad-based phenotyping of a knockout (KO) mouse line for every protein-coding gene, producing a multidimensional data set that underlies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35944064
DOI: 10.1371/journal.pbio.3001723
PMCID: PMC9391051

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