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Article

Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion.

PloS one - 1 Jan 2013

Geng Yue, Chandrasekaran Siddarth, Hsu Jong-Wei, Gidwani Mishka, Hughes Andrew D, King Michael R

Abstract excerpt

Hematogeneous metastasis can occur via a cascade of circulating tumor cell adhesion events to the endothelial lining of the vasculature, i.e. the metastatic cascade. Interestingly, the pro-inflammatory cytokines IL-6 and TNF-α, which play an important role in potentiating the inflammatory cascade, are significantly elevated in metastatic breast cancer (BCa) patients. Despite their high metastatic potential, human...

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PMID: 23372803
DOI: 10.1371/journal.pone.0054959
PMCID: PMC3553003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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