Article
Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2011
Yano Seiji, Yamada Tadaaki, Takeuchi Shinji, Tachibana Keisei, Minami Yuko, Yatabe Yasushi, Mitsudomi Tetsuya, Tanaka Hidenori, Kimura Tatsuo, Kudoh Shinzoh, Nokihara Hiroshi, Ohe Yuichiro, Yokota Jun, Uramoto Hidetaka, Yasumoto Kosei, Kiura Katsuyuki, Higashiyama Masahiko, Oda Makoto, Saito Haruhiro, Yoshida Junji, Kondoh Kazuya, Noguchi Masayuki
Abstract excerpt
INTRODUCTION: This study was performed to determine the incidence rates of resistance factors, i.e., high-level hepatocyte growth factor (HGF) expression, epidermal growth factor receptor (EGFR) T790M secondary mutation, and MET amplification, in tumors with intrinsic and acquired EGFR tyrosine kinase inhibitor (TKI) resistance in EGFR mutant lung cancer. METHODS: Ninety-seven specimens from 93 EGFR mutant lung...
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