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Article

SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer

23 Jun 2021

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence, understanding the molecular mechanisms underlying early invasion and metastasis by PDAC is imperative for improving patient outcomes. The present study identified that upregulation of TSPAN8 expression in PDAC facilitates metastasis in vivo...

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PMID: 34163029
DOI: 10.1038/s41388-021-01864-9

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