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Article

The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer

31 Oct 2018

Abstract excerpt

Pancreatic cancer, mostly pancreatic ductal adenocarcinomas (PDAC), is one of the most lethal cancers, with a dismal median survival around 8 months. PDAC is notoriously resistant to chemotherapy. Thus far, numerous attempts using novel targeted therapies and immunotherapies yielded limited clinical benefits for pancreatic cancer patients. It is hoped that delineating the molecular mechanisms underlying drug...

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PMID: 30382189
DOI: 10.1038/s41388-018-0553-0

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