Article
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.
Scientific reports - 11 Mar 2021
Kantar Diala, Mur Emilie Bousquet, Mancini Maicol, Slaninova Vera, Salah Yezza Ben, Costa Luca, Forest Elodie, Lassus Patrice, Géminard Charles, Boissière-Michot Florence, Orsetti Béatrice, Theillet Charles, Colinge Jacques, Benistant Christine, Maraver Antonio, Heron-Milhavet Lisa, Djiane Alexandre
Abstract excerpt
Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased...
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