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Article

Suppressor-type TERT mutations associated with recurrence in ovarian clear cell carcinoma.

Genes, chromosomes & cancer - 1 Aug 2023

Kobayashi Tatsuya, Nishikimi Kyoko, Mitsuhashi Akira, Piao Hongying, Matsuoka Ayumu, Otsuka Satoyo, Tate Shinichi, Shozu Makio, Usui Hirokazu

Abstract excerpt

Several cancers harbor "enhancer-type" mutations of the telomerase reverse transcriptase (TERT) promoter for immortalization. Here, we report that 8.6% (8/93) of ovarian clear cell carcinomas (OCCCs) possess the "suppressor-type" TERT promoter mutation. The recurrence rate of OCCCs with "suppressor-type" TERT promoter mutations was 62.5% (5/8) and was significantly higher than that of the "unaffected-type" with...

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PMID: 36710084
DOI: 10.1002/gcc.23129

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