Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.

PloS one - 1 Jan 2014

Barbisan Fernanda, Motta Jéssica de Rosso, Trott Alexis, Azzolin Verônica, Dornelles Eduardo Bortoluzzi, Marcon Matheus, Algarve Thaís Doeler, Duarte Marta Maria Medeiros Frescura, Mostardeiro Clarice Pinheiro, Unfer Taís Cristina, Schott Karen Lilian, da Cruz Ivana Beatrice Mânica

Abstract excerpt

Methotrexate (MTX) is a folic acid antagonist used in high doses as an anti-cancer treatment and in low doses for the treatment of some autoimmune diseases. MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation. Despite the oxidative effect of MTX, the influence of antioxidant gene polymorphisms on MTX toxicity is not well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluoresceins

Share to Gene Expression Regulation, Enzymologic

Share to Lipid Peroxidation

Share to Methotrexate

Share to Reactive Oxygen Species

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 25330300
DOI: 10.1371/journal.pone.0107299
PMCID: PMC4203676

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.PMID 25330300Read ↗

Cytotoxic effects of moderate static magnetic field exposure on human periphery blood mononuclear cells are influenced by Val16Ala-MnSOD gene polymorphism.Semantic proximity Read ↗

The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism.Semantic proximity Read ↗

Toxicological effects of ultraviolet radiation on lymphocyte cells with different manganese superoxide dismutase Ala16Val polymorphism genotypes.Semantic proximity Read ↗

In vitro effects of Ala16Val manganese superoxide dismutase gene polymorphism on human white blood cells exposed to methylmercury.Semantic proximity Read ↗

Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process?Semantic proximity Read ↗

Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells.Semantic proximity Read ↗

Thiopurine Biotransformation and Pharmacological Effects: Contribution of Oxidative Stress.Semantic proximity Read ↗

Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.Semantic proximity Read ↗

Effects of 47C allele (rs4880) of the SOD2 gene in the production of intracellular reactive species in peripheral blood mononuclear cells with and without lipopolysaccharides induction.Semantic proximity Read ↗

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS PatientsSemantic proximity Read ↗

Gene expression, levels and polymorphism (Ala16Val) of mitochondrial superoxide dismutase in tuberculosis patients of Rajasthan.Semantic proximity Read ↗

The Association of GSTT1, GSTM1, and TNF-α Polymorphisms With the Risk and Outcome in Multiple MyelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.