Article
Toxicological effects of ultraviolet radiation on lymphocyte cells with different manganese superoxide dismutase Ala16Val polymorphism genotypes.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2010
dos Santos Montagner Greice Franciele Feyh, Sagrillo Michele, Machado Michel Mansur, Almeida Renata Chequeller, Mostardeiro Clarice Pinheiro, Duarte Marta Maria Medeiros Frescura, da Cruz Ivana Beatrice Mânica
Abstract excerpt
The aim of this study was to investigate whether there is a differential response of lymphocytes from healthy MnSOD genotype subjects to oxidative stress. We used UV radiation as a toxic agent due to its genotoxic effects associated with chromosome aberrations caused by breaks in the DNA strands. Cellular growth rate, cell viability, mitotic index, chromosomal instability and biomarkers of oxidative metabolism...
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