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Article

Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4).

PLoS genetics - 1 Oct 2014

Key Felix M, Peter Benjamin, Dennis Megan Y, Huerta-Sánchez Emilia, Tang Wei, Prokunina-Olsson Ludmila, Nielsen Rasmus, Andrés Aida M

Abstract excerpt

Interferon lambda 4 gene (IFNL4) encodes IFN-λ4, a new member of the IFN-λ family with antiviral activity. In humans IFNL4 open reading frame is truncated by a polymorphic frame-shift insertion that eliminates IFN-λ4 and turns IFNL4 into a polymorphic pseudogene. Functional IFN-λ4 has antiviral a...

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Identifiers

PMID: 25329461
DOI: 10.1371/journal.pgen.1004681
PMCID: PMC4199494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25329461-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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