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Article

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2015

Tsotakos Nikolaos, Silveyra Patricia, Lin Zhenwu, Thomas Neal, Vaid Mudit, Floros Joanna

Abstract excerpt

Surfactant protein A (SP-A), a molecule with roles in lung innate immunity and surfactant-related functions, is encoded by two genes in humans: SFTPA1 (SP-A1) and SFTPA2 (SP-A2). The mRNAs from these genes differ in their 5'-untranslated regions (5'-UTR) due to differential splicing. The 5'-UTR variant ACD' is exclusively found in transcripts of SP-A1, but not in those of SP-A2. Its unique exon C contains two...

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Identifiers

PMID: 25326576
DOI: 10.1152/ajplung.00058.2014
PMCID: PMC4281701

Genes

ACD
SFTPA1
SFTPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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