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Article

SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.

The American journal of physiology - 1 Jun 1999

Hoover R R, Floros J

Abstract excerpt

The synthetic glucocorticoid dexamethasone has a major inhibitory effect on human surfactant protein A1 (SP-A1) and SP-A2 gene expression that occurs at both the transcriptional and posttranscriptional levels. Toward the identification of cis-acting elements that may be involved in the dexamethasone regulation of SP-A mRNA stability, chimeric chloramphenicol acetyltransferase (CAT) constructs that contained...

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Source

Identifiers

PMID: 10362715
DOI: 10.1152/ajplung.1999.276.6.L917

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.PMID 10362715Read ↗

Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone.Semantic proximity Read ↗

Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene.Semantic proximity Read ↗

Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes.Semantic proximity Read ↗

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.Semantic proximity Read ↗

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.Semantic proximity Read ↗

Sequences of a hairpin structure in the 3'-untranslated region mediate regulation of human pulmonary surfactant protein B mRNA stability.Semantic proximity Read ↗

Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.Semantic proximity Read ↗

An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture.Semantic proximity Read ↗

Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic miceSemantic proximity Read ↗

Human SP-A: then and now.Semantic proximity Read ↗

5' splicing and allelic variants of the human pulmonary surfactant protein A genes.Semantic proximity Read ↗

Characterization of a second human pulmonary surfactant-associated protein SP-A gene.Semantic proximity Read ↗

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