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Article

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Lopez-Pelaez Marta, Lamont Douglas J, Peggie Mark, Shpiro Natalia, Gray Nathanael S, Cohen Philip

Abstract excerpt

The siRNA knockdown of IFN Regulatory Factor 5 (IRF5) in the human plasmacytoid dendritic cell line Gen2.2 prevented IFNβ production induced by compound CL097, a ligand for Toll-like receptor 7 (TLR7). CL097 also stimulated the phosphorylation of IRF5 at Ser462 and stimulated the nuclear transloc...

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Share to Active Transport, Cell Nucleus
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Proteins

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Source

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Identifiers

PMID: 25326418
DOI: 10.1073/pnas.1418399111
PMCID: PMC4267347

Genes

TLR7
NOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25326418-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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