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Article

Silencing the wild-type and mutant K-ras increases the resistance to 5-flurouracil in HCT-116 as a colorectal cancer cell line.

Anti-cancer drugs - 1 Feb 2015

Teimoori-Toolabi Ladan, Hashemi Saba, Azadmanesh Kayhan, Eghbalpour Farnaz, Safavifar Farnaz, Khorramizadeh Mohammad Reza

Abstract excerpt

Colon cancer is the second to third common cancer worldwide. Several efforts have been made to reveal the pathways responsible for drug resistance in this type of cancer. We aimed to investigate the effect of silencing both mutant and wild-type Kristen Rous sarcoma (k-ras) on the response of human colorectal tumor 116 (HCT-116) as a colon cancer cell line to the cytotoxic effect of 5-flurouracil (5-FU). One...

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Identifiers

PMID: 25325304
DOI: 10.1097/CAD.0000000000000175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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