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Article

Silencing SATB1 inhibits the malignant phenotype and increases sensitivity of human osteosarcoma U2OS cells to arsenic trioxide.

International journal of medical sciences - 1 Jan 2014

Zhang Haiying, Su Xuejin, Guo Li, Zhong Lingzhi, Li Wenxue, Yue Zhen, Wang Xiaotong, Mu Yan, Li Xinna, Li Ronggui, Wang Zonggui

Abstract excerpt

In a previous study, we found that the global genome organizer Special AT-rich binding protein 1 (SATB1) is highly expressed in mesenchymal-derived human osteosarcoma U2OS cells and that the knock-down of SATB1 results in the inhibition of cell proliferation. The present study was aimed at investigating the effect of silencing SATB1 on cell migration, invasion, apoptosis and resistance to the chemotherapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25317073
DOI: 10.7150/ijms.10038
PMCID: PMC4196128

Genes

SATB1
ABCC1
ABCG2

Provenance

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Silencing SATB1 inhibits the malignant phenotype and increases sensitivity of human osteosarcoma U2OS cells to arsenic trioxide.PMID 25317073Read ↗

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