Article
A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway.
Stem cell research & therapy - 4 Dec 2021
Xin Tianyi, Li Qian, Bai Rushui, Zhang Ting, Zhou Yanheng, Zhang Yuehua, Han Bing, Yang Ruili
Abstract excerpt
BACKGROUND: SATB2-associated syndrome (SAS) is a multisystem disorder caused by mutation of human SATB2 gene. Tooth agenesis is one of the most common phenotypes observed in SAS. Our study aimed at identifying novel variant of SATB2 in a patient with SAS, and to investigate the cellular and molecular mechanism of tooth agenesis caused by SATB2 mutation. METHODS: We applied whole exome sequencing (WES) to identify...
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