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Article

Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.

Journal of cancer research and therapeutics - 1 Jan 2000

Mhaidat Nizar M, Al-azzam Sayer I, Alzoubi Karem H, Khabour Omar F, Gharaibeh Baraa F

Abstract excerpt

CONTEXT: The human granzyme B protein (GrB), which is encoded by granzyme B gene (GZMB), plays a major role in eliminating cancer cells. Polymorphisms of GZMB gene such as Q55R, P94A, and Y247H have been shown to affect GrB activity and the subsequent cancer risk. AIMS: In this study, we examined...

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Source

Identifiers

PMID: 25313744
DOI: 10.4103/0973-1482.137940

Genes

GZMB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25313744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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