Article
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.
Nature genetics - 1 Nov 2014
Zhang Ming, Wang Yuxuan, Jones Sian, Sausen Mark, McMahon Kevin, Sharma Rajni, Wang Qing, Belzberg Allan J, Chaichana Kaisorn, Gallia Gary L, Gokaslan Ziya L, Riggins Greg J, Wolinksy Jean-Paul, Wood Laura D, Montgomery Elizabeth A, Hruban Ralph H, Kinzler Kenneth W, Papadopoulos Nickolas, Vogelstein Bert, Bettegowda Chetan
Abstract excerpt
Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12,...
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