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Article

Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2011

Eggers John P, Grandgenett Paul M, Collisson Eric C, Lewallen Michelle E, Tremayne Jarrod, Singh Pankaj K, Swanson Benjamin J, Andersen Judy M, Caffrey Thomas C, High Robin R, Ouellette Michel, Hollingsworth Michael A

Abstract excerpt

PURPOSE: To evaluate the nature of cyclin-dependent kinase 5 (CDK5) hyperactivity in pancreatic cancer progression. EXPERIMENTAL DESIGN: We used genetic, biochemical, and molecular biology methods to investigate the nature and function of overexpression of CDK5 and its activators p35 and p39 during the progression of pancreatic cancer. RESULTS: Amplification of the CDK5 gene or either of its main activators, p35...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21825040
DOI: 10.1158/1078-0432.CCR-10-2288
PMCID: PMC3425449

Genes

CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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