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Article

The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukemia.

Human pathology - 1 Dec 2014

Federmann Birgit, Abele Manuel, Rosero Cuesta David Santiago, Vogel Wichard, Boiocchi Leonardo, Kanz Lothar, Quintanilla-Martinez Leticia, Orazi Attilio, Bonzheim Irina, Fend Falko

Abstract excerpt

Diagnosis of chronic myelomonocytic leukemia (CMML) is based on a combination of clinical, laboratory, and morphological parameters, including persistent peripheral blood monocytosis. Recently, mutations of serine/arginine-rich splicing factor 2 (SRSF2) have been identified in 40% to 50% of CMMLs and occasionally in other myeloid disorders. In this study, we established a robust assay for the detection of SRSF2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25305095
DOI: 10.1016/j.humpath.2014.08.014

Genes

SRSF2
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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