Prevalence and clinical features of the mitochondrial m.1555A>G mutation in Taiwanese patients with idiopathic sensorineural hearing loss and association of haplogroup F with low penetrance in three families.

Abstract excerpt

OBJECTIVE: The m.1555A>G mutation in the mitochondria 12S rRNA gene has been reported to be an important cause of nonsyndromic hereditary hearing loss. However, remarkable interfamilial and intrafamilial variations in the phenotypes of the mutation preclude precise prognosis during genetic counseling. Hence, this study was performed to explore the factors that might contribute to the differences in the...

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