Article
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.
Cancer causes & control : CCC - 1 Jan 2011
Tong Seo-yun, Kim Mi Kyung, Lee Jae Kwan, Lee Jong Min, Choi Sang Woon, Friso Simonetta, Song Eun-Seop, Lee Kwang Beom, Lee Jung Pil
Abstract excerpt
OBJECTIVE: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. METHODS: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75 years). RESULTS: Patients with...
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