Article
Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction.
Developmental biology - 1 Dec 2014
Lockhart Marie M, Boukens Bastiaan J D, Phelps Aimee L, Brown Christina-Lin M, Toomer Katelynn A, Burns Tara A, Mukherjee Rupak D, Norris Russell A, Trusk Thomas C, van den Hoff Maurice J B, Wessels Andy
Abstract excerpt
Recent studies using mouse models for cell fate tracing of epicardial derived cells (EPDCs) have demonstrated that at the atrioventricular (AV) junction EPDCs contribute to the mesenchyme of the AV sulcus, the annulus fibrosus, and the parietal leaflets of the AV valves. There is little insight, however, into the mechanisms that govern the contribution of EPDCs to these tissues. While it has been demonstrated...
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